Michael P Whyte Selected Research

burosumab

1/2022	Sustained Efficacy and Safety of Burosumab, a Monoclonal Antibody to FGF23, in Children With X-Linked Hypophosphatemia.
1/2022	Effect of Burosumab Compared With Conventional Therapy on Younger vs Older Children With X-linked Hypophosphatemia.
1/2021	Tumor-Induced Osteomalacia: Treatment Progress Using Burosumab, an Anti-FGF23 Monoclonal Antibody.
1/2021	Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia.
1/2019	Burosumab versus conventional therapy in children with X-linked hypophosphataemia: a randomised, active-controlled, open-label, phase 3 trial.
1/2019	Efficacy and safety of burosumab in children aged 1-4 years with X-linked hypophosphataemia: a multicentre, open-label, phase 2 trial.
1/2018	Burosumab Therapy in Children with X-Linked Hypophosphatemia.

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Michael P Whyte Research Topics

Disease

45	Hypophosphatasia 01/2022 - 01/2002
28	Rickets (Rachitis) 01/2022 - 04/2003
22	Osteomalacia 01/2022 - 11/2006
11	Metabolic Bone Diseases (Osteopenia) 12/2021 - 08/2007
10	Pain (Aches) 01/2021 - 10/2008
9	Congenital Abnormalities (Deformity) 01/2022 - 09/2008
8	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2022 - 06/2009
8	Infantile Hypophosphatasia 01/2019 - 02/2002
7	Hypercalcemia (Milk Alkali Syndrome) 11/2018 - 06/2007
6	Osteoporosis 01/2020 - 11/2006
6	Osteopetrosis 11/2018 - 07/2003
6	Bone Diseases (Bone Disease) 06/2015 - 09/2008
5	Adult Hypophosphatasia 12/2021 - 04/2007
5	Hyperostosis corticalis deformans juvenilis 01/2020 - 07/2002
5	Tooth Loss 01/2020 - 04/2014
4	Osteosclerosis 01/2020 - 10/2008
4	Craniosynostoses (Craniosynostosis) 01/2019 - 06/2015
4	Femoral Fractures (Femoral Fracture) 01/2014 - 11/2006
3	Seizures (Absence Seizure) 01/2022 - 06/2007
3	Hypophosphatemia 01/2022 - 02/2013
3	Arterial calcification of infancy 01/2020 - 02/2013
3	Hyperphosphatemia 01/2020 - 04/2007
3	Joint Diseases (Joint Disease) 09/2017 - 04/2014
3	Pyridoxine-dependent epilepsy 09/2017 - 06/2008
3	Osteitis Deformans (Paget's Disease of Bone) 11/2014 - 04/2004
3	Neoplasms (Cancer) 04/2014 - 10/2005
3	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia 03/2008 - 04/2004
2	Hepatitis C 01/2021 - 01/2016
2	Hypocalcemia 01/2021 - 03/2012
2	Secondary Hyperparathyroidism 01/2021 - 08/2011
2	X-Linked Hypoparathyroidism 01/2020 - 12/2004
2	Hyperostosis 01/2020 - 05/2007
2	Failure to Thrive 01/2020 - 01/2019
2	Contracture 01/2020 - 02/2013
2	Enthesopathy 01/2020 - 01/2019
2	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 01/2020 - 01/2019
2	Periarthritis 01/2019 - 04/2014
2	Respiratory Insufficiency (Respiratory Failure) 01/2019 - 01/2013
2	Arthritis (Polyarthritis) 11/2018 - 10/2005
2	Nephrocalcinosis 11/2018 - 06/2007
2	Arthralgia (Joint Pain) 11/2018 - 08/2011
2	Body Weight (Weight, Body) 01/2018 - 08/2011
2	Muscle Weakness 04/2016 - 01/2016
2	Primary Myelofibrosis (Myelosclerosis) 01/2016 - 09/2012
2	hereditary expansile Polyostotic osteolytic dysplasia 11/2014 - 04/2014
2	Disease Progression 09/2008 - 06/2007
2	Frontotemporal Dementia (Semantic Dementia) 03/2008 - 04/2004
2	Muscular Diseases (Myopathy) 03/2008 - 04/2004
1	Calcinosis 01/2022
1	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2022
1	Abscess 01/2022
1	Pica (Geophagia) 01/2021

Drug/Important Bio-Agent (IBA)

46	Alkaline PhosphataseIBA 01/2022 - 01/2002
34	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2022 - 06/2006
31	IsoenzymesIBA 01/2022 - 02/2002
12	diphosphoric acid (pyrophosphoric acid)IBA 01/2021 - 06/2007
10	Phosphates (Orthophosphate)IBA 01/2022 - 01/2016
10	PyridoxalIBA 01/2021 - 01/2002
9	CalciumIBA 01/2020 - 09/2012
8	Vitamin D FDA LinkGeneric 01/2022 - 05/2011
8	asfotase alfaIBA 01/2021 - 08/2011
7	Fibroblast Growth Factor-23IBA 01/2022 - 12/2005
7	burosumabIBA 01/2022 - 01/2018
7	Diphosphonates (Bisphosphonates)IBA 12/2021 - 07/2003
6	Monoclonal AntibodiesIBA 01/2022 - 09/2012
6	MineralsIBA 01/2022 - 12/2013
6	Vitamin B 6IBA 01/2022 - 06/2007
6	Durapatite (Hydroxylapatite)IBA 01/2019 - 08/2009
5	Phosphorus (Red Phosphorus)IBA 01/2021 - 01/2018
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 02/2002
5	EnzymesIBA 01/2018 - 04/2010
5	OsteoprotegerinIBA 04/2016 - 07/2002
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 02/2002
4	Biomarkers (Surrogate Marker)IBA 11/2018 - 04/2007
4	Pamidronate (Aredia)FDA LinkGeneric 12/2014 - 10/2008
3	Teriparatide (Parathar)FDA Link 12/2021 - 04/2007
3	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/2020 - 05/2007
3	Parathyroid Hormone (Parathormone)IBA 01/2020 - 08/2016
3	Tetracycline (Achromycin)FDA LinkGeneric 01/2017 - 01/2007
3	RANK LigandIBA 09/2012 - 07/2002
2	TeaIBA 01/2021 - 08/2011
2	hydroxide ionIBA 01/2020 - 08/2011
2	alpha2 Subunit Collagen Type IIBA 01/2020 - 06/2011
2	Protein Isoforms (Isoforms)IBA 01/2020 - 02/2013
2	OsteopontinIBA 01/2020 - 01/2017
2	CreatinineIBA 01/2019 - 01/2002
2	phosphorylethanolamine (phosphoethanolamine)IBA 08/2016 - 06/2007
2	Protein Sorting Signals (Signal Peptide)IBA 11/2014 - 04/2014
2	OsteocalcinIBA 02/2013 - 02/2005
2	GlucuronidaseIBA 09/2012 - 04/2010
2	GlycosaminoglycansIBA 09/2012 - 04/2010
2	VitaminsIBA 08/2012 - 01/2002
2	Pharmaceutical PreparationsIBA 03/2012 - 10/2008
2	Valosin Containing ProteinIBA 02/2006 - 04/2004
1	SaltsIBA 01/2022
1	gamma-Aminobutyric Acid (GABA)IBA 01/2022
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2022
1	Anabolic AgentsIBA 01/2021

Therapy/Procedure

16	Therapeutics 01/2022 - 11/2006
4	Enzyme Replacement Therapy 01/2019 - 06/2008